생명공학대학 - 생명공학대학

  • 조교수 바이오의약품 전달
  • 박우람
    Lab 첨단바이오의약품전달 연구실

관심분야

Drug Delivery, Nanoparticles, Lipid Nanoparticle (LNP), mRNA Delivery, Hybrid Materials, Cancer Immunotherapy, Biomedical Imaging, Cell Engineering, Medical Devices

학력

  • (2015, Ph.D.) Department of Biotechnology, The Catholic University of Korea
  • (2008, B.S.) Department of Biotechnology, The Catholic University of Korea

약력/경력

  • (2022 ~ Present) Assistant Professor, Department of Integrative Biotechnology, Sungkyunkwan University, Republic of Korea
  • (2020 ~ 2022) Assistant Professor, Department of Biomedical Chemical Engineering, The Catholic University of Korea
  • (2017 ~ 2020) Assistant Professor, Department of Biomedical Science, College of Life Sciences, CHA University, Republic of Korea
  • (2015 ~ 2017) Research Associate (Postdoctoral fellow), Department of Radiology, Northwestern University Feinberg School of Medicine, USA

학술지 논문

  • (2024)  An electro-ferroptotic nanoammunition enables image-guided, spatiotemporally controlled cancer ferroptosis induction via irreversible electroporation.  CHEMICAL ENGINEERING JOURNAL.  487, 
  • (2024)  Enhancing CAR-NK Cells Against Solid Tumors Through Chemical and Genetic Fortification with DOTAP-Functionalized Lipid Nanoparticles.  ADVANCED FUNCTIONAL MATERIALS.  1,  1
  • (2024)  M1-polarized macrophage-derived cellular nanovesicle-coated lipid nanoparticles for enhanced cancer treatment through hybridization of gene therapy and cancer immunotherapy.  ACTA PHARMACEUTICA SINICA B.  1,  1
  • (2023)  Anti-Inflammatory Artificial Extracellular Vesicles with Notable Inhibition of Particulate Matter-Induced Skin Inflammation and Barrier Function Impairment.  ACS APPLIED MATERIALS & INTERFACES.  15,  51
  • (2023)  3D-printed NIR-responsive bullets as multifunctional nanodrug platforms for image-guided local chemo-photothermal therapy.  CHEMICAL ENGINEERING JOURNAL.  477, 
  • (2023)  Lipid nanoparticle-based mRNA delivery systems for cancer immunotherapy.  NANO CONVERGENCE.  10,  1
  • (2023)  The ELK3-DRP1 axis determines the chemosensitivity of triple-negative breast cancer cells to CDDP by regulating mitochondrial dynamics.  CELL DEATH DISCOVERY.  9,  1
  • (2023)  Systemic Delivery of a STING Agonist-Loaded Positively Charged Liposome Selectively Targets Tumor Immune Microenvironment and Suppresses Tumor Angiogenesis.  SMALL.  19,  43
  • (2023)  Uniform Gold Nanostructure Formation via Weakly Adsorbed Gold Films and Thermal Annealing for Reliable Localized Surface Plasmon Resonance-Based Detection of DNase-I.  SMALL.  19,  39
  • (2023)  Multifunctional porous microspheres encapsulating oncolytic bacterial spores and their potential for cancer immunotherapy.  BIOMATERIALS SCIENCE.  11,  13
  • (2023)  Nanoparticle-Based Chimeric Antigen Receptor Therapy for Cancer Immunotherapy.  TISSUE ENGINEERING AND REGENERATIVE MEDICINE.  20,  3
  • (2023)  Hybrid nanovesicle of chimeric antigen receptor (CAR)-engineered cell-derived vesicle and drug-encapsulated liposome for effective cancer treatment.  JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY.  122, 
  • (2023)  Reprogramming the tumor microenvironment with biotechnology.  BIOMATERIALS RESEARCH.  27,  1
  • (2022)  Liposome-mediated small RNA delivery to convert the macrophage polarity: A novel therapeutic approach to treat inflammatory uterine disease.  MOLECULAR THERAPY-NUCLEIC ACIDS.  30,  -
  • (2022)  Biofunctional Layered Double Hydroxide Nanohybrids for Cancer Therapy.  MATERIALS.  15,  22
  • (2022)  Cabozantinib-Loaded PLGA Nanoparticles: A Potential Adjuvant Strategy for Surgically Resected High-Risk Non-Metastatic Renal Cell Carcinoma.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.  23,  20
  • (2022)  Image-guided in situ cancer vaccination with combination of multi-functional nano-adjuvant and an irreversible electroporation technique.  BIOMATERIALS.  289, 
  • (2022)  Reactive Oxygen Species Responsive Cleavable Hierarchical Metallic Supra-Nanostructure.  SMALL.  18,  38
  • (2022)  Flexible 3D Nanonetworked Silica Film as a Polymer-Free Drug-Eluting Stent Platform to Effectively Suppress Tissue Hyperplasia in Rat Esophagus.  ADVANCED HEALTHCARE MATERIALS.  11,  14
  • (2022)  Combination of Metal-Phenolic Network-Based Immunoactive Nanoparticles and Bipolar Irreversible Electroporation for Effective Cancer Immunotherapy.  SMALL.  18,  25

수상/공훈

  • (2021) PHI BIOMED Young Scientist Award, Korean Society for Biomaterials
  • (2021) MIWON COMMERCIAL Young Scientist Award, The Korean Society of Industrial and Engineering Chemistry
  • (2020) MEDIPOST Young Scientist Award Korean, Korean Tissue Engineering and Regenerative Medicine Society
  • (2013) Korean and Japanese Biomaterials Societies Young Scientist Exchange Program Award, The Korean and Japanese Society for Biomaterials